BIOLOGY 3411, FALL 2009

Monday, Wednesday, Friday

Rebstock 215

Class begins on Wednesday, August 26 10:00-11:00 AM

Instructors

Dr. Larry Salkoff, Coursemaster, 362-3644, salkoffl@pcg.wustl.edu

Dr. Thomas Woolsey, 362-3601, woolseyt@wustl.edu

TAs: 

Jacob Basson            414-405-3460        jacob.basson@gmail.com
Ronny Dosenbach         618-610-6213        ronnyd@wustl.edu
Cynthia Garcia         951-236-4086        cgarcia@artsci.wustl.edu
Harry Papadimitriou         314-306-6561        papadimitriou.c@gmail.com
Rachel Smith        623-570-8425        resmith@artsci.wustl.edu
Yasuko Suzuki         314-369-3896        ysuzuki@artsci.wustl.edu

 

Textbook required: NEUROSCIENCE by Purves, et al, 4th edition.  

Reference: THE BRAIN ATLAS by Woolsey, Hanaway and Gado, 3rd edition.  Copies are on reserve in Olin Library.

 

Discussion Section Assignments (tba)

Please note, the schedule has changed for Nov. 20 onward


AIntroduction to & Overview of the Nervous System

Wednesday, August 26 - Lecture I.   Introduction to the Course. (L. Salkoff) .


 

Friday, August 28 - Lecture II.   The Nervous System and Its Cells. (T. Woolsey)

Reading Slides Other

pp. 4-17 of The Brain Atlas, 3rd ed.

Jellison et al. 2004 .

Power Point Slides

PDF of slides

Play the Brain Movie

Worksheet


                          

B. Development

Monday, August 31 - Lecture III: The Embryology of the Nervous System

Reading Slides Other
 

Power Point Slides

PDF of Slides

zf  early divisions movie

grey crescent movie

ventral migration mpg

Xenopus gastrulation movie


Wednesday, September 02 - Lecture IV: Mechanisms of Neural Development .  

Reading Slides Other

Hemmati-Brivanlou Rev Cell 97

Groppe_et.pdf

Fainsod_et.pdf

Zimmerman_et.pdf

Xanthos_et.pdf

Wilson_Gen.pdf

Weeks_Melton.pdf

Smith_Harland.pdf

Sasai_DeRobertis.pdf

Melton.pdf

Power Point Slides

PDF of Slides

 

 


Friday, September 4- Discussion 1


 Monday, September 07 - Labor day, No Class


Wednesday, September 09 - Lecture V: Cell Death .  

Reading Slides Other

Abbot 2009

Raff 1998

Holliday 2001

Hengartner 2000

Cohen 1986

PowerPoint Slides

PDF of Slides

Apoptosis movie


Friday, September 11 - Discussion 2.  


Monday, September 14 - Lecture VI: Making Connections

Reading Slides Other

Consent

 

PowerPoint Slides

PDF of Slides

Cone Movie


Wednesday, September 16 - Lecture VII: CNS Patterning 

Reading Slides Other

Puelles.pdf

Hartenstein 2008.pdf

Hartenstein Atlas.pdf

Benito-Gutierrez.pdf

PowerPoint Slides

PDF of Slides

Human Embryo Fetal Stages - jpg


Friday, September 18 - Discussion 3.  


C. Brain Pathways and Functions (T. Woolsey)  

Monday, September 21 - Lecture VIII. Spinal Cord, Reflexes and Brain Pathways

 

Reading Slides Other

 

PowerPoint Slides

PDF of Slides

 

Wednesday, September 23 - Lecture IX: Sensation

Reading Slides Other

Mogil

Godwin

Cox

PowerPoint Slides

PDF  of  Slides

 

 

Friday, September 25 - Discussion 4.  


Monday, September 28 - Lecture X. Movement

 

Reading Slides Other

Vulliemoz

Tovar-Moll

Sicotte

Gleeson

PowerPoint Slides

PDF of Slides

 

Wednesday, September 30- Lecture XI: Integrating Functions

Reading Slides Other

Baxter, 2002

Bell, 2006

Clements, 2006

Einstein, 1999

Keenan, 2001

Schlaug, 1995

Shaywitz et al. 1995

 PowerPoint Slides

 PDF of Slides

RBC's.mov


Friday, October 02- Discussion 5


Monday, October 05 - Lecture XII: Experience and Critical Periods.

Reading Slides Other

Fair et al.

Hernandez, 2001

Knott et al., 2002

Kim et al., 1997

Lazar, 2005

Levy, 2007

Martin et al., 1996a

Martin et al., 1996b

Shimony et al

Woolsey, 2003

 

 PowerPoint Slides

 PDF of Slides

 Fair Movie Clip


 

D. Lessons from Brain Disorders (T. Woolsey)  

Wednesday, October 07 - Lecture XIII. Brain Diseases. I.

Reading Slides Other

Starr 98

Gulie 07

Barker 99

 PowerPoint Slides

 PDF of Slides

MJF-Limbaughx.mov

Perlmutter.mp3

PD #3 (OR).mov


Friday, October 09 - Lecture XIV. Brain Diseases. II.

Reading Slides Other

Drevets 98

Fu 99

Breiter

97Nemeroff

PowerPoint Slides

PDF of Slides

 

Monday, October 12 - Lecture XV: Genetics and Human Brains: Clues from Abnormalities 

Reading Slides Other

Amado & Walsh 06

Vulliemoz 05

McKusick wins Japan Prize

Yaklovlev & Rakic 66

Lin2007.pdf

MetabolicCity.pdf

 

 PowerPoint Slides

 PDF of Slides

vmjr-brain.mp4

YoungFrankStem.mp4


Wednesday, October 14 - Lecture XVI: Reflections on Higher Brain Functions (L. Salkoff)


Friday, October 16 - Fall Break - No Class


Monday, October 19 - Discussion 6


Wednesday, October 21 - Review Session .


Friday, October 23 - Midterm Exam  - Review for Midterm PDF


 

E. Electrical Properties of the Brain (L. Salkoff)  

Monday, October 26 - Lecture XVII: Membranes and Bioelectricity.

Wednesday, October 28- Lecture XVIII. The Resting Potential.

Friday, October 30 - Discussion 7

Monday, November 02- Lecture XIX: Voltage-Gated Ion Channels.

Wednesday, November 04 - Lecture XX: Ion Channels and Action Potentials.

Friday, November 06- Discussion 8.  

 

Monday, November 09 - Lecture XXI. Diversity of Ion Channels..


F. The Synapse and Complex Electrical Behavior (L. Salkoff)  

Wednesday, November 11 - Lecture XXII:   Chemical Transmission: Ligand-gated Ion Channels.

Friday, November 13- Discussion 9.

Monday, November 16- Lecture XXIII:   Synaptic Potentials/Synaptic Integration.

Wednesday, November 18 - Lecture XXIV:   Heterogeneity of Neurotransmitters and Receptors.

Friday, November 20 - Discussion 10

Monday, November 23- Lecture XXV. Synaptic Plasticity - LTP

Wednesday, November 25 - Thanksgiving break, no class

Friday, November 27 - Thanksgiving break, no class

Monday, November 30 - Lecture XXVI.   Learning and Memory

Wednesday, December 02- Lecture XXVII. Ion Channels and Disease, Natural Genetic Variation and Human Behavior

Friday, December 04 - Discussion 11 and Review


G. Final Review (Monday, December 7)

Reading Slides Other

Review Article PDF

   

 


H. Final Exam (Tuesday, December 15 - 215 Rebstock, 10:30 am - 12:30 pm)

 

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