Ursula Goodenough

Title:	Professor of Biology Associate Professor of Anatomy
Degree:	PHD, Harvard University MA, Columbia University BA, Barnard College
Dept:	Biology
Office:	McDonnell Hall 215A
Mailbox:	Campus Box 1229 One Brookings Drive St. Louis, MO 63130-4899 Hide Full Mailing Address
Phone:	(314) 935-6836
E-mail:	goodenough@wustl.edu

Courses
Cell Biology; Epic of Evolution: Life, Earth, and Cosmos; Introduction to Cell Biology

Research Interests
Professor Goodenough, Patrick Ferris, and colleagues are studying the molecular basis and evolution of life-cycle transitions in the flagellated green alga, Chlamydomonas reinhardtii. They have cloned genes in the mating-type (mt) locus and genes regulated by mt that control the transition between vegetative growth and gametic differentiation and zygote development. These include genes responsible for mate recognition, uniparental inheritance of chloroplast DNA, and gametic differentiation, allowing them to study their function and their evolution during speciation.

Selected Publications:

Ferris, P.J., Goodenough, U.W. (1997) Mating type in Chlamydomonas is specified by mid, the minus-dominance gene. Genetics 146: 859-869.

Ferris, P.J., Pavlovic, C., Fabry, S., Goodenough, U.W. (1997) Rapid evolution of sex-related genes in Chlamydomonas. Proc. Natl. Acad. Sci. USA 94: 8634-8639.

Umen, J.G., Goodenough, U.W. (2001) Chloroplast DNA methylation and inheritance in Chlamydomonas. Genes Dev. 15: 2585-2597.

Umen, J.G., Goodenough, U.W. (2001) Control of cell division by a retinoblastoma protein homolog in Chlamydomonas. Genes Dev. 15: 1652-1661.

Ferris, P.J., Woessner, J.P., Waffenschmidt, S., Kilz, S., Drees, J., Goodenough, U.W. (2001) Glycosylated polyproline II rods with kinks as a structural motif in plant hydroxy-proline-rich glycoproteins. Biochemistry 40: 2978-2987.

Ferris, P.J., Armbrust, E.V., Goodenough, U.W. (2002) Genetic structure of the mating-type locus of Chlamydomonas reinhardtii. Genetics 160: 181-200.