Douglas Chalker

An advanced exploration of the structure and function of DNA within the eukaryotic nucleus. Lecture and discussion cover topics of chromatin and chromosome structure, control of gene transcription, RNA processing, and DNA replication and repair. The relevance of these topics to the genetic basis of human disease is discussed. Throughout, the experimental data that shape our current understanding are emphasized. Course grades based on exams, problem sets and short papers. Lecture 3 hours per week plus required discussion section meeting every other week. Prerequisites: Bio 2970, Chem 261 (may be taken concurrently). Offered every other fall in even numbered years.

This research-intensive course provides an introduction to diverse molecular and cytological techniques used in model experimental organisms to explore fundamental biological questions. Experiments are performed using selected fungi and protozoans commonly used in major research efforts. Emphasis is placed on choosing the appropriate organism for the question posed using the most current technologies. Each student selects an uncharacterized gene to study in detail, conducting an original research project. Writing assignments model the components of scientific articles with the final paper reporting the cumulative findings of the semester-long project. Students also present their research during the poster session of the undergraduate research symposium. Prerequisites: Bio 2960 and 2970 and permission of instructor-- contact instructor early to ensure enrollment. One hour of lecture and six hours of laboratory a week. Fulfills the upper-level laboratory requirement for the Biology major and is writing intensive. Enrollment limited to 16.

Recent biomedical discoveries have been greatly advanced through the development of innovative, state-of-the-art techniques. For example, Nuclear Magnetic Resonance (NMR) has proved to be an invaluable tool in both efforts to determine the atomic structure of proteins and small molecules as well as in clinical settings. This course introduces students to a variety of cutting-edge laboratory techniques and discusses the impact of these techniques on biology and medicine. Students have the unique opportunity to learn from graduate students employing these approaches in their doctoral studies. Topics include: human brain neuroimaging, next-generation DNA sequencing, CRISPR-Cas gene editing and many more. Weekly classes consist of a 30-45 minute presentation on a particular technique, followed by 60-minute discussion of the assigned readings. Students will be evaluated on class participation, answers to weekly research based questions and two longer written assignments. Prerequisites: Biology 2960 and 2970 and at least one semester of BIO500 or equivalent research experience approved by the course master.

A broad overview of genetics, including Mendelian assortment, linkage, chromosomal aberrations, variations in chromosome number, mutation, developmental genetics, quantitative genetics, population genetics, mechanisms of evolution, and phylogenetics.